NINDS Kleine-Levin Syndrome Information Page : Sleep Disorders

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General Health : Sleep Disorders

Last Updated: Oct 6, 2009 - 12:07:30 PM

NINDS Kleine-Levin Syndrome Information Page
By nih.gov
Jul 27, 2006 - 9:57:00 AM

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Table of Contents (click to jump to sections)
What is Kleine-Levin Syndrome?
Is there any treatment?
What is the prognosis?
What research is being done?

Organizations
Related NINDS Publications and Information

What is Kleine-Levin Syndrome?
Kleine-Levin syndrome is a rare disorder that causes recurring periods of excessive drowsiness and sleep (up to 20 hours per day). Symptoms, which may last for days to weeks, include excessive food intake, irritability, disorientation, lack of energy, and hypersensitivity to noise. Some patients may also experience hallucinations and an abnormally uninhibited sex drive. Affected persons are normal between episodes, although depression and amnesia may be noted temporarily after an attack. It may be weeks or more before symptoms reappear. Onset is typically around adolescence to the late teens. The disorder is 4 times more common in males than in females. Symptoms may be related to malfunction of the hypothalamus, the part of the brain that governs appetite and sleep.

Is there any treatment?

There is no definitive treatment for Kleine-Levin syndrome. Stimulants, including amphetamines, methylphenidate and modafinil, administered orally, are used to treat sleepiness. Because of similarities between Kleine-Levin syndrome and certain mood disorders, lithium and carbamazepine may be prescribed. Responses to treatment have often been limited. This disorder needs to be differentiated from cyclic re-occurrence of sleepiness during the premenstrual period in teenaged girls that may be controlled with birth control pills.

What is the prognosis?

The disorder appears to be benign and does not impact on intellect or physical function. Symptoms usually improve or disappear with advancing age.

What research is being done?

NINDS supports a broad range of clinical and basic research on diseases causing sleep disorders, in an effort to clarify the mechanisms of these conditions and to develop better treatments for them.

Select this link to view a list of studies currently seeking patients.

Organizations

National Sleep Foundation
1522 K Street NW
Suite 500
Washington, DC 20005
nsf@sleepfoundation.org
http://www.sleepfoundation.org
Tel: 202-347-3471
Fax: 202-347-3472

National Organization for Rare Disorders (NORD)
P.O. Box 1968
(55 Kenosia Avenue)
Danbury, CT 06813-1968
orphan@rarediseases.org
http://www.rarediseases.org
Tel: 203-744-0100 Voice Mail 800-999-NORD (6673)
Fax: 203-798-2291

Related NINDS Publications and Information

Brain Basics: Understanding Sleep
Fact sheet on normal sleep and sleep disorders developed by the National Institute of Neurological Disorders and Stroke (NINDS).

Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892

NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined that patient or is familiar with that patient's medical history.

All NINDS-prepared information is in the public domain and may be freely copied. Credit to the NINDS or the NIH is appreciated.

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Last updated June 13, 2006

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