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General Health : Heart Cardiovascular Last Updated: Oct 6, 2009 - 12:07:30 PM

What is Heart Disease ?
By NIH
May 10, 2005 - 11:21:00 AM

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Heart disease is a general term that refers to a variety of acute and chronic medical conditions that affect one or more of the components of the heart. Located in the left side of the chest cavity, the heart is a muscular, fist-sized organ that continuously pumps blood, beating as many as 100,000 times a day. The blood that the heart moves carries oxygen and nutrients throughout the body and transports carbon dioxide and other wastes away. The heart ensures its own oxygen supply through a set of coronary arteries and veins. The heart is also an endocrine organ that produces the hormones atrial natriuretic hormone (ANP) and B-type natriuretic peptide (BNP), which coordinate heart function with blood vessels and the kidneys.
Internally, the heart is essentially hollow. It is divided vertically into two halves by a septum, and each side of the heart has two internal chambers ¨C an atrium on top and a ventricle on the bottom. Venous blood enters the right side of the heart through the right atrium and is pumped by the right ventricle to the lungs. Oxygenated blood from the lungs enters the left atrium and is pumped by the left ventricle into arteries that carry it throughout the body. Four heart valves regulate the direction and flow of blood through the heart. It is their opening and shutting that gives the heart its characteristic ¡°lub-dub¡± beat. The heart muscle itself is called the myocardium. Lining the chambers of the heart and the valves is a membrane called the endocardium. Encasing the outside of the heart is the pericardium ¨C a layered membrane that is fibrous on the outside and serous (fluid-secreting) on the inside. The pericardium forms a protective barrier around the heart and allows it to beat in a virtually friction free environment.

Diseases affecting the heart may be structural or functional. Anything that damages the heart, makes it less efficient, reduces its ability to fill and pump, or decreases the heart¡¯s supply of oxygen will disrupt the coordinated relationship between the heart, kidneys, and blood vessels and will harm not only the heart but the rest of the body as well.

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