Other Theories About Causes of Fibromyalgia

Some have speculated that lower levels of a brain neurotransmitter called serotonin leads to lowered pain thresholds or an increased sensitivity to pain. It's associated with a calming, anxiety-reducing reaction. The lowered pain thresholds in fibromyalgia patients may be caused by the reduced effectiveness of the body's natural endorphin painkillers and the increased presence of a chemical called "substance P." Substance P amplifies pain signals.

There have been some studies that link fibromyalgia to sudden trauma to the brain and spinal cord. Keep in mind, though, theories about what causes fibromyalgia are merely speculative.

Does Stress Cause Fibromyalgia?

Some researchers theorize that stress or poor physical conditioning are factors in the cause of fibromyalgia. Another theory suggests that muscle "microtrauma" (very slight damage) leads to an ongoing cycle of pain and fatigue. This mechanism, like all the others, is still unproven for fibromyalgia.

Do Insomnia or Sleep Disorders Cause Fibromyalgia?

Most people with fibromyalgia experience insomnia or non-restorative sleep -- sleep that is light and not refreshing. Disordered sleep might lead to lower levels of serotonin, which results in increased pain sensitivity. Researchers have created a lower pain threshold in women by depriving them of sleep, possibly simulating fibromyalgia.

Is Depression Linked to Fibromyalgia?

Some scientists used to believe that because fibromyalgia was accompanied by low-grade depression, there may be a link between the two illnesses. Today, mental health issues are no longer thought to cause fibromyalgia. However, chronic pain can cause feelings of anxiety and depression, which may worsen fibromyalgia symptoms.

Is Fibromyalgia Hereditary?

Like other rheumatic diseases, fibromyalgia could be the result of a genetic tendency that's passed from mother to daughter. Some researchers believe that a person's genes may regulate the way his or her body processes painful stimuli. These scientists theorize that people with fibromyalgia may have a gene or genes that cause them to react intensely to stimuli that most people would not perceive as painful. To date, these genes have not been isolated or identified.