What are diabetes problems?

Too much glucose (sugar) in the blood for a long time can cause diabetes problems. This high blood glucose (also called blood sugar) can damage many parts of the body, such as the heart, blood vessels, eyes, and kidneys. Heart and blood vessel disease can lead to heart attacks and strokes. You can do a lot to prevent or slow down diabetes problems.

This booklet is about kidney problems caused by diabetes. You will learn the things you can do each day and during each year to stay healthy and prevent diabetes problems.

Your kidneys are two bean-shaped organs about the size of your
fist. They are located just below the rib cage, near your back.

What should I do each day to stay healthy with diabetes?

	Follow the healthy eating plan that you and your doctor or dietitian have worked out.
	Be active a total of 30 minutes most days. Ask your doctor what activities are best for you.
	Take your medicines as directed.
	Check your blood glucose every day. Each time you check your blood glucose, write the number in your record book.
	Check your feet every day for cuts, blisters, sores, swelling, redness, or sore toenails.
	Brush and floss your teeth every day.
	Control your blood pressure and cholesterol.
	Don't smoke.

What do my kidneys do?

The kidneys act as filters to clean the blood. They get rid of waste and send along filtered fluids. The tiny filters in the kidneys are called glomeruli (gloh-MEHR-yoo-lie).

When kidneys are healthy, the artery (AR-ter-ee) brings blood and waste from the bloodstream into the kidney. The glomeruli clean the blood. Then waste and extra fluid go out into the urine through the ureter. Clean blood leaves the kidney and goes back into the bloodstream through the vein.

You have two kidneys. Your kidneys clean your blood and
make urine. This drawing shows a cross section of a kidney.

How can I prevent diabetes kidney problems?

• Keep your blood glucose as close to normal as you can. Ask your doctor what blood glucose numbers are healthy for you.
  
  
• Keep your blood pressure below 130/80 to help prevent kidney damage. Blood pressure is written with two numbers separated by a slash. For example, 120/70 is said as ¡°120 over 70.¡±
  
  Ask your doctor what numbers are best for you. If you take blood pressure pills every day, take them as your doctor tells you. Keeping your blood pressure under control will also slow down or prevent damage to your eyes, heart, and blood vessels.

Keep your blood pressure below 130/80.

• Ask your doctor if you should take pills to slow down kidney damage. Two kinds are available:
  
  
  • ACE (angiotensin [an-gee-oh-TEN-sin] converting enzyme) inhibitor (in-HIB-it-ur)
    
    
  • ARB (angiotensin receptor blocker)
    
    
• Follow the healthy eating plan you work out with your doctor or dietitian. If you already have kidney problems, your dietitian may suggest that you cut back on protein, such as meat.
  
  
• Have your kidneys checked at least once a year by having your urine tested for small amounts of protein. This test is called the microalbumin (MY-kro-al-BYOO-min) test.
  
  
• Have your blood tested at least once a year for creatinine (kree-AT-ih-nin). The result of this test should be used to estimate your glomerular (gloh-MEHR-yoo-ler) filtration rate (GFR), a measure of kidney function.

Pills can help you control your blood pressure and slow down kidney damage.

• Have any other kidney tests that your doctor thinks you need.
  
  
• Avoid taking painkillers regularly. Daily use of pills like aspirin or acetaminophen can damage the kidneys. Taking a single dose of aspirin every day to protect the heart, however, should be safe. And taking acetaminophen for occasional pain should also be safe. But if you are dealing with chronic pain, such as arthritis, work with your doctor to find a way to control your pain without putting your kidneys at risk.
  
  
• See a doctor for bladder or kidney infections right away. You may have an infection if you have these symptoms:
  • pain or burning when you urinate
    
    
  • frequent urge to go to the bathroom
    
    
  • urine that looks cloudy or reddish
    
    
  • fever or a shaky feeling
    
    
  • pain in your back or on your side below your ribs
    

How can my doctor protect my kidneys during special x-ray tests?

X-ray tests using a contrast agent pose a risk to your kidneys. If you need x rays, your doctor can give you extra water before and after the x ray to protect your kidneys. Or your doctor may decide to order a test that does not use a contrast agent.

How can diabetes hurt my kidneys?

When kidneys are working well, the tiny filters in your kidneys, the glomeruli, keep protein inside your body. You need the protein to stay healthy.

High blood glucose and high blood pressure damage the kidneys?filters. When the kidneys are damaged, the protein leaks out of the kidneys into the urine. Damaged kidneys do not do a good job of cleaning out waste and extra fluids. Waste and fluids build up in your blood instead of leaving the body in urine.

Kidney damage begins long before you notice any symptoms. An early sign of kidney damage is when your kidneys leak small amounts of a protein called albumin (al-BYOO-min) into the urine. But the only way to know about this leakage is to have your urine tested.

With more damage, the kidneys leak more and more protein. This problem is called proteinuria (PRO-tee-NOOR-ee-uh). More and more wastes build up in the blood. This damage gets worse until the kidneys fail.

Diabetic nephropathy (neh-FROP-uh-thee) is the medical term for kidney problems caused by diabetes. Nephropathy affects both kidneys at the same time.

	No protein is leaking from the healthy kidney.
	Protein is leaking from the unhealthy kidney.

What can I do if I have kidney problems caused by diabetes?

Once you have kidney damage, you cannot undo it. But you can slow it down or stop it from getting worse by controlling your blood pressure, taking your ACE inhibitors or ARBs, and having your kidney function tested regularly.

Keeping blood pressure under control helps to keep your kidneys healthy.

How will I know if my kidneys fail?

At first, you cannot tell. Kidney damage from diabetes happens so slowly that you may not feel sick at all for many years. You will not feel sick even when your kidneys do only half the job of normal kidneys. You may not feel any signs of kidney failure until your kidneys have almost stopped working. However, getting your urine and blood checked every year can tell you how well your kidneys are working.

Once your kidneys fail, you may feel sick to your stomach and feel tired all the time. Your hands and feet may swell from extra fluid in your body.

You may feel sick to your stomach when your kidneys stop working.

What happens if my kidneys fail?

One way to treat kidney failure is with dialysis (dy-AL-ih-sis). Dialysis is a treatment that does the work your kidneys used to do. There are two types of dialysis (see page 12). You and your doctor will decide what type will work best for you.

Dialysis is a treatment that takes waste products and extra fluid out of your body.

1. Hemodialysis (HEE-moh-dy-AL-ih-sis). In hemodialysis, your blood flows through a tube from your arm to a machine that filters out the waste products and extra fluid. The clean blood flows back to your arm.
   
   
2. Peritoneal dialysis (PEH-rih-tuh-NEE-ul dy-AL-ih-sis). In peritoneal dialysis, your belly is filled with a special fluid. The fluid collects waste products and extra water from your blood. Then the fluid is drained from your belly and thrown away.

Another way to treat kidney failure is to have a kidney transplant. This operation gives you a new kidney. The kidney can be from a close family member, friend, or someone you do not know. You may be on dialysis for a long time. Many people are waiting for new kidneys. A new kidney must be a good match for your body.

Will I know if I start to have kidney problems?

No. You will know you have kidney problems only if your doctor checks your blood for creatinine and your urine for protein. Do not wait for signs of kidney damage to have your blood and urine checked.

How can I find out if I have kidney problems?

Two lab tests can tell you and your doctor how well your kidneys are working.

• Each year make sure your doctor checks a sample of your urine to see if your kidneys are leaking small amounts of protein called microalbumin.
  
  
• At least once each year, your doctor should check your blood to measure the amount of creatinine. Creatinine is a waste product your body makes. If your kidneys are not cleaning waste products from your blood, they can build up and make you sick. Your doctor can use your creatinine level to check your GFR. GFR stands for glomerular filtration rate. Results of this test tell you how well your kidneys are removing wastes from the blood.

For More Information

Diabetes Teachers (nurses, dietitians, pharmacists, and other health professionals)

To find a diabetes teacher near you, call the American Association of Diabetes Educators toll-free at 1¨C800¨CTEAMUP4 (1¨C800¨C832¨C6874), or look on the Internet at www.diabeteseducator.org and click on ¡°Find an Educator.¡±

Dietitians

To find a dietitian near you, call the American Dietetic Association toll-free at 1¨C800¨C366¨C1655, or look on the Internet at www.eatright.org and click on ¡°Find a Nutrition Professional.¡±

Government

The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) is part of the National Institutes of Health. To learn more about kidney problems, write or call NKUDIC, 3 Information Way, Bethesda, MD 20892?580, 1¨C800¨C891¨C5390; or see www.kidney.niddk.nih.gov on the Internet.

The National Kidney Disease Education Program (NKDEP) is part of the National Institutes of Health. To learn more about kidney problems, write or call NKDEP, 3 Kidney Information Way, Bethesda, MD 20892, 1¨C866¨C454¨C3639; or see www.nkdep.nih.gov on the Internet.

To get more information about taking care of diabetes, contact

National Diabetes Information Clearinghouse
1 Information Way
Bethesda, MD 20892¨C3560
Phone: 1¨C800¨C860¨C8747
Fax: 703¨C738¨C4929
Email: ndic@info.niddk.nih.gov
Internet: www.diabetes.niddk.nih.gov

National Diabetes Education Program
1 Diabetes Way
Bethesda, MD 20892¨C3600
Phone: 1¨C800¨C438¨C5383
Fax: 703¨C738¨C4929
Internet: www.ndep.nih.gov

American Diabetes Association
1701 North Beauregard Street
Alexandria, VA 22311
Phone: 1¨C800¨C342¨C2383
Internet: www.diabetes.org

Juvenile Diabetes Research Foundation International
120 Wall Street
19th Floor
New York, NY 10005¨C4001
Phone: 1¨C800¨C533¨C2873
Internet: www.jdrf.org

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More in the Series

The "Prevent Diabetes Problems" series includes seven booklets that can help you learn more about how to prevent diabetes problems.

• Keep Your Diabetes Under Control
• Keep Your Eyes Healthy
• Keep Your Feet and Skin Healthy
• Keep Your Heart and Blood Vessels Healthy
• Keep Your Kidneys Healthy
• Keep Your Nervous System Healthy
• Keep Your Teeth and Gums Healthy

For free single copies of these booklets, write, call, fax, or email the

National Diabetes Information Clearinghouse
1 Information Way
Bethesda, MD 20892¨C3560

Phone: 1¨C800¨C860¨C8747
Fax: 703¨C738¨C4929
Email: ndic@info.niddk.nih.gov

These booklets are also available at www.diabetes.niddk.nih.gov on the Internet.

Acknowledgments

The National Diabetes Information Clearinghouse thanks the people who helped review or field-test this publication.

National Diabetes Information Clearinghouse

1 Information Way
Bethesda, MD 20892¨C3560
Email: ndic@info.niddk.nih.gov

The National Diabetes Information Clearinghouse (NDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health under the U.S. Department of Health and Human Services. Established in 1978, the Clearinghouse provides information about diabetes to people with diabetes and to their families, health care professionals, and the public. The NDIC answers inquiries, develops and distributes publications, and works closely with professional and patient organizations and Government agencies to coordinate resources about diabetes.

Publications produced by the Clearinghouse are carefully reviewed by both NIDDK scientists and outside experts.

This publication is not copyrighted. The Clearinghouse encourages users of this publication to duplicate and distribute as many copies as desired.

NIH Publication No. 06¨C4281
March 2006